SIDE EFFECTS OF ANTIRETROVIRAL TREATMENT (ART)

The treatment available in allopathy system of medicine is a class of drugs called anti-retrovirals. These drugs does not cure HIV but drastically reduce the amount of virus in the blood there by preventing progression towards AIDS.



Currently there are more than 20 anti-retroviral drugs available for treatment in the allopathic system of medicine. The anti-retroviral treatment (ART) in allopathy usually consist of taking a combination of two or more anti-retroviral drugs a day. These drugs cause severe side effects especially when taken for a longer duration of time.

Anti-retroviral drugs in western medicine mainly falls into the following seven categories like 


  1. Nucleoside Reverse Transcriptase Inhibitors
  2. Non-Nucleoside Reverse Transcriptase Inhibitors
  3. Protease Inhibitors
  4. Fusion Inhibitors
  5. Chemokine Coreceptor Antagonists
  6. Integrase Inhibitors
  7. Pharmacokinetic Enhancers


NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS

ABACAVIR - Its side effects are as follows:

  • Rashes
  • Headache, nausea, vomiting, diarrhea
  • Hypersensitivity syndrome like fever, myalgia, upper respiratory tract infection 

DIDANOSINE - Its side effects are as follows:

  •  Pancreatitis
  • Peripheral neuroapathy
  • Nausea, diarrhea

LAMIVUDINE - Its side effects are as follows:

  •  Headache, dry mouth

STAVUDINE - Its side effects are as follows:

  • Peripheral Neuropathy
  • Pancreatitis
  • Dyslipidemia
  • Diarrhea

EMTRICITABINE - Its side effects are as follows:

  •  Headache, nausea, insomnia
  • Hyperpigmentation of palms and soles

TENOFOVIR - Its side effects are as follows:

  •  Flatulence, nausea, diarrhea, abdominal discomfort
  • Asthenia
  • Acute renal insufficiency, Fanconi syndrome
  • Chronic Renal insufficiency

ZIDOVUDINE - Its side effects are as follows:

  •  Anemia
  • Fatigue, malaise
  • Nausea, vomiting
  • Myalgia, myopathy
  • Hyperpigmentation of skin and nails

Nonnucleoside Reverse Transcriptase Inhibitors

DELAVIRDINE - Its side effects are as follows:

  • Fatigue
  • Elevations in liver function tests, hepatitis
  • Nausea, diarrhea
EFAVIRENZ - Its side effects are as follows:

  • Abnormal dreams, drowsiness, dizziness, confusion
  • Mood changes
  • Elevations in liver function tests
  • Hyperlipidemia
ETRAVIRINE - Its side effects are as follows:
  • Elevations in liver function tests

NEVIRAPINE - Its side effects are as follows:

  • Elevations in liver function tests, hepatitis, liver failure

PHARMACOKINETIC ENHANCERS

COBICISTAT - Its side effects are as follows:

  • Increased Serum creatinine, proteiuria
  • Nausea, diarrhea
  • Headache


INTEGRASE INHIBITORS


RALTEGRAVIR - Its side effects are as follows:


  • Nausea, diarrhea, flatulence
  • Elevations in amylase and liver function tests
  • Headache
  • Dizziness, abnormal dreams
  • Pruritus, rash
  • Fatigue, muscle pain


FUSION INHIBITORS


ENFUVIRTIDE - Its side effects are as follows:

  • Injection site reactions; erythema, cysts, and nodules at injection sites
  • Neutropenia
  • Possible increased frequency of pneumonia